Toxicology of Paracetamol Poisoning

  Paracetamol or acetaminophen is commonly used over the counter painkiller (NSAID/analgesic and antipyretic). The drug has certain minor pharmacological differences with regards to its mechanism. Unfortunately, probably due to its easy availability they are a common choice to commit suicide. The manufacturer recommended safe dose of 4g divided over a 24 hour period. The…

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Insulin

Infectious diseases were the epicenter of the last millennium , metabolic issues are said to be dominant of the present era. First recipient of insulin was a 14 year old boy from Canada, 11th Jan 1922. Isolated in crystalline form by Abel in 1930. Human Insulin is produced by recombinant DNA technology,  structural alterations at…

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Cannabis, a wonder drug?

Introduction Cannabis is one of the most widely used substances for recreational purposes, and also the most controversial substance. The more you keep something restricted, the more curiosity is generated. The stories and myths surrounding cannabis are many so much so that one can get confused with what is real and what is a lie.…

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Use of LMWH (Low molecular Weight Heparins ) in treating Venous Thromboembolism (VTE)

The risk of having Venous Thromboembolism (VTE) in cancer patients is high due to poor prognosis. VTE as such is an independent risk factor for cancer, and there is an increase in incidence by 7-fold to develop VTE in cancer patients. It is estimated that around 15-20% of patients with Pulmonary Embolism (PE) or Deep-Vein…

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Hemophilia

X- linked recessive hemorrhagic disease due to the mutation in the F8 gene ( Hemophilia A ), and F9 gene is responsible for Hemophilia B. Since it is an X linked disorder males are clinically more affected than females. Males have XY chromosome, so if the X chromosome is affected the Y isn’t able to…

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Pain and it’s management

Incidence, Prevalence and Epidemiology It is a state of unpleasant sensory and emotional experience associated with actual and potential tissue damage or described in terms of such damage. It is an essential response of our body to warn us or signal us of potential injury. The most common types of pain occur in the back…

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Cardiovascular Disorders: Introduction to terminologies

Common conditions of the cardiovascular system, which will present in all the cardio chapters, so we have put forth the terms and a short information.   Aortic Valve Disease Aortic Valve is one of the valves that control the flow of the blood into and out of the heart. The flow of the oxygenated blood…

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Thyroid Disorders

Introduction  Thyroid abnormalities affect women more than men, around 5 % of the population suffers from this disorder of the endocrine gland. This condition has a diverse manifestation because of the thyroid gland’s involvement in cellular differentiation and proliferation in virtually all nucleated cells of the body. Thyroid Physiology Thyroid gland consists of two lobes…

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